A 20yo lady is suffering from fever and loss of appetite. She has been dx with toxoplasmosis
What is the tx?
a. Pyrimethamine
b. Pyrimethamine + sulfadiazine
c. Clindamycin
d. Spiramycin
e. Trimethoprim + sulfamethoxazole
answer: B
Treatment and Prevention
• no treatment if: immunocompetent, not pregnant, no severe organ damage
• pregnancy: spiramycin to prevent transplacental transmission or pyrimethamine + sulfadiazine (add folinic acid), avoid undercooked meat and refrain from emptying cat litter boxes
• Immuno-comprimised: pyrimethamine + sulfadiazine
• eye disease, meningitis: corticosteroids
• proper hand hygiene, cook meat thoroughly to proper temperature
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