Splenomegaly , fever, anemia (260/1700)

A 57yo man presents with weight loss, tiredness, fever and abdominal discomfort. Exam: spleen
palpable up to the umbilicus. Labs: WBC=127, Hgb=8.7, Plt=138. What is the most likely dx?

a. CML
b. AML
c. CLL
d. AML
e. Polycythemia






























CML > splenomegaly in more than 75%, hepatmegaly+ lymphadenopathy rare
CLL> would have lymphadenopathy
AML> splenomegaly and hepatomegaly 20%, plus things like gum hypertrophy