A 45yo woman comes with red, swollen and exudating ulcer on the nipple and areola of right
breast with palpable lump under the ulcer. What do you think is causing this skin condition?
a. Inflammatory cells releasing cytokines
b. Infiltration of the lymphatics by the carcinomatous cells
c. Infiltration of the malignant skin cells to the breast tissue
answer: B
Inflammatory carcinoma
Š ductal carcinoma that invades dermal lymphatics
Š most aggressive form of breast cancer
Š clinical features: erythema, skin edema, warm, swollen and tender breast ± lump
Š peau d’orange indicates advanced disease (IIIb-IV)
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