A 51yo man has become increasingly fatigued for the past 10m. PE: no abnormal findings. Labs:
Hgb=9.2, Hct=27.9%, MCV=132fl, plt=242, WBC=7.59. Which of the following morphologic
findings is most likely to be present on examination of his peripheral blood smear?
a. Hypersegmented neutrophils
b. Nucleated RBC
c. Blasts
d. Hypochromic, microcytic RBC
e. Schistocytes
answer: A
high MCV = macrocytic anemia
DD megaloblastic anemias
B12 deficiency
Folate deficiency
Megaloblastic anaemias are a heterogeneous group of disorders that share
common morphological characteristics. Erythrocytes are larger and have
higher nuclear-to-cytoplasmic ratios compared to normoblastic cells.
Neutrophils can be hypersegmented and megakaryocytes are abnormal.
No comments:
Post a Comment