A 39yo woman has not had her period for 10months. She feels well but is anxious as her mother
had an early menopause. Choose the single most appropriate initial inv?
a. Serum estradiol conc.
b. Serum FSH/LH
c. Serum progesterone conc.
d. None
e. Transvaginal US
answer: B
Investigations of Menopause
• increased levels of FSH (>35 IU/L) on day 3 of cycle (if still cycling) and LH (FSH>LH)
• FSH level not always predictive due to monthly variation; use absence of menses for 1 yr to diagnose
• decreased levels of estradiol (later)
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